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Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in Uganda.

Lubinski B, Frazier LE, Phan MVT, Bugembe DL, Cunningham JL, Tang T, Daniel S, Cotten M, Jaimes JA, Whittaker GR.Microbiol Spectr. 2022 Jun 29:e0151422. doi: 10.1128/spectrum.01514-22. PMID: 35766497

SARS-CoV-2 electrochemical immunosensor based on the spike-ACE2 complex.

Vásquez V, Navas MC, Jaimes JA, Orozco J.Anal Chim Acta. 2022 May 1;1205:339718. doi: 10.1016/j.aca.2022.339718. PMID: 35414393

Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry.

Kastenhuber ER, Mercadante M, Nilsson-Payant B, Johnson JL, Jaimes JA, Muecksch F, Weisblum Y, Bram Y, Whittaker GR, tenOever BR, Schwartz RE, Chandar V, Cantley L. Elife. 2022 Mar 16;11:e77444. doi: 10.7554/eLife.77444. PMID: 35294338

Functional evaluation of the P681H mutation on the proteolytic activation of the SARS-CoV-2 variant B.1.1.7 (Alpha) spike.

Lubinski B, Fernandes MHV, Frazier L, Tang T, Daniel S, Diel DG, Jaimes JA, Whittaker GR. iScience. 2022 Jan 21;25(1):103589. doi: 10.1016/j.isci.2021.103589. PMID: 34909610

Inhibitors of L-Type Calcium Channels Show Therapeutic Potential for Treating SARS-CoV-2 Infections by Preventing Virus Entry and Spread.

Straus MR, Bidon MK, Tang T, Jaimes JA, Whittaker GR, Daniel S. ACS Infect Dis. 2021 Sep 9:acsinfecdis.1c00023. doi: 10.1021/acsinfecdis.1c00023. PMID: 34498840


SARS-CoV-2 Clinical Outcome in Domestic and Wild Cats: A Systematic Review.

Giraldo-Ramirez S, Rendon-Marin S, Jaimes JA, Martinez-Gutierrez M, Ruiz-Saenz J. Animals (Basel). 2021 Jul 9;11(7):2056. doi: 10.3390/ani11072056. PMID: 34359182

Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda.

Frazier L, Lubinski B, Tang T, Daniel S, Jaimes JA, Whittaker G. bioRxiv. 2021 Jul 5:2021.06.30.450632. doi: 10.1101/2021.06.30.450632. Preprint. PMID: 3423093

Molecular diversity of coronavirus host cell entry receptors.

Millet JK, Jaimes JA, Whittaker GR. FEMS Microbiol Rev. 2021 May 5;45(3):fuaa057. doi: 10.1093/femsre/fuaa057. PMID: 33955468

One Medicine: a comparative approach to investigating human and animal coronavirus infections.

Stout AE, André NM, Jaimes JA, Licitra BN, Whittaker GR. J Feline Med Surg. 2021 Apr;23(4):267-268. doi: 10.1177/1098612X21998904. PMID: 33761776

Functional evaluation of proteolytic activation for the SARS-CoV-2 variant B.1.1.7: role of the P681H mutation.

Lubinski B, Tang T, Daniel S, Jaimes JA, Whittaker GR. bioRxiv. 2021 Apr 8:2021.04.06.438731. doi: 10.1101/2021.04.06.438731. Preprint. PMID: 33851153

Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry.

Kastenhuber ER, Jaimes JA, Johnson JL, Mercadante M, Muecksch F, Weisblum Y, Bram Y, Schwartz RE, Whittaker GR, Cantley LC. bioRxiv. 2021 Apr 1:2021.03.31.437960. doi: 10.1101/2021.03.31.437960. Preprint. PMID: 33821268

SARS CoV-2 Spike Protein in silico Interaction With ACE2 Receptors From Wild and Domestic Species.

Rendon-Marin S, Martinez-Gutierrez M, Whittaker GR, Jaimes JA, Ruiz-Saenz J. Front Genet. 2021 Feb 15;12:571707. doi: 10.3389/fgene.2021.571707. eCollection 2021. PMID: 33659022 

Proteolytic Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of Proteases beyond Furin.

Tang T, Jaimes JA, Bidon MK, Straus MR, Daniel S, Whittaker GR. ACS Infect Dis. 2021 Feb 12;7(2):264-272. doi: 10.1021/acsinfecdis.0c00701. Epub 2021 Jan 12. PMID: 33432808

Coronaviruses in cats and other companion animals: Where does SARS-CoV-2/COVID-19 fit?

Stout AE, André NM, Jaimes JA, Millet JK, Whittaker GR. Vet Microbiol. 2020 Aug;247:108777. doi: 10.1016/j.vetmic.2020.108777. Epub 2020 Jun 23. PMID: 32768223

Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site.

Jaimes JA, Millet JK, Whittaker GR. iScience. 2020 Jun 26;23(6):101212. doi: 10.1016/j.isci.2020.101212. Epub 2020 May 28. PMID: 32512386

Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop.

Jaimes JA, André NM, Chappie JS, Millet JK, Whittaker GR. J Mol Biol. 2020 May 1;432(10):3309-3325. doi: 10.1016/j.jmb.2020.04.009. Epub 2020 Apr 19. PMID: 32320687

Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals aproteolytically-sensitive activation loop as a distinguishing feature compared to SARS-CoV and related SARS-like coronaviruses.

Jaimes JA, Andre NM, Millet JK, Whittaker GR. ArXiv. 2020 Feb 14:arXiv:2002.06196v1. Preprint. PMID: 32550245

Coronavirus membrane fusion mechanism offers a potential target for antiviral development.

Tang T, Bidon M, Jaimes JA, Whittaker GR, Daniel S. Antiviral Res. 2020 Jun;178:104792. doi: 10.1016/j.antiviral.2020.104792. Epub 2020 Apr 6. PMID: 32272173

A Tale of Two Viruses: The Distinct Spike Glycoproteins of Feline Coronaviruses.

Jaimes JA, Millet JK, Stout AE, André NM, Whittaker GR. Viruses. 2020 Jan 10;12(1):83. doi: 10.3390/v12010083. PMID: 31936749

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting.

Millet JK, Tang T, Nathan L, Jaimes JA, Hsu HL, Daniel S, Whittaker GR. J Vis Exp. 2019 Mar 1;(145):10.3791/59010. doi: 10.3791/59010. PMID: 30882796

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation.

Jaimes JA, Millet JK, Goldstein ME, Whittaker GR, Straus MR. J Vis Exp. 2019 Jan 9;(143). doi: 10.3791/58892. PMID: 30688313

Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function.

Jaimes JA, Whittaker GR. Virology. 2018 Apr;517:108-121. doi: 10.1016/j.virol.2017.12.027. Epub 2018 Jan 10. PMID: 29329682

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